Syphilis: Testing, Treatment and Follow-Up
Learn how syphilis tests are interpreted, why previous treatment matters and when to get prompt clinical assessment.
A sore may disappear while infection remains
Early syphilis can cause a painless sore that is easy to miss. A later rash can come and go. Someone may have no noticeable signs for long periods. Tell a clinician if a partner was diagnosed or if you notice a sore or rash after a possible exposure.
Blood tests answer different questions
Laboratories commonly use two types of blood tests, called treponemal and nontreponemal tests, to help interpret the result. Some antibodies can remain detectable after successful treatment. Take previous results or treatment dates to the visit. A reactive home test needs clinical evaluation, and a recent negative test may need repeating.
Get appropriate treatment and follow-up
Syphilis is curable. Clinicians choose the treatment and follow-up schedule based on the stage of infection, pregnancy and the areas affected. In pregnancy, seek prompt care after a possible exposure or reactive result. Seek urgent medical assessment for new vision, hearing or neurological symptoms that may be associated with syphilis. Ask the clinic about partner notification and follow-up blood tests.
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